Hair-cycle dependent differential expression of ADAM 10 and ADAM 12

ADAM 10 ( ADAM metallopeptidase domain 10 )

ADAM 12: A Putative Marker of Oligodendrogliomas?

ADAM 12 (meltrin alpha) belongs to a large family of molecules, consisting of members with both disintegrin and metalloproteinase properties. ADAMs have been implicated in several cell physiological processes including cell adhesion, cell fusion, proteolysis and signalling. ADAM 12 is widely expressed, including skeletal muscle, testis, bone, intestine, heart and kidney. In addition, a variety ...

Modeling of enzyme-substrate complexes for the metalloproteases MMP-3, ADAM-9 and ADAM-10

The matrix metalloproteases (MMPs) and the ADAMs (A Disintegrin And Metalloprotease domain) are proteolytic enzyme families containing a catalytic zinc ion, that are implicated in a variety of normal and pathological processes involving tissue remodeling and cancer. Synthetic MMP inhibitors have been designed for applications in pathological situations. However, a greater understanding of subst...

Adam Kilgarriff

A long time ago now (maybe 1988?), Gerald (Gazdar) and I supervised Adam’s DPhil at the University of Sussex. Adam was my age, give or take a year, having come to academia a little late, and was my first doctoral student. Adam’s topic was polysemy, and I’m not really sure that much supervision was actually required, though I recall fun exchanges trying to model the subtleties of word meaning us...

Adam Miklósi

An overview The picture that emerges when one looks at the global situation for funding in ecology and evolution is that, while all biological research is suffering, these fields are faring somewhat worse. Surprisingly, this is despite the fact that research in evolution and ecology will be vital if we are to stand a chance of solving the problem of increasing numbers of humans on a planet that...